480-19-3

Name	Isorhamnetin
CAS	480-19-3
EINECS(EC#)	207-545-5
Molecular Formula	C31H42O7
MDL Number	MFCD00017310
Molecular Weight	526.66
MOL File	480-19-3.mol

Synonyms

3,5,7,4'-TETRAHYDROXY-3'-METHOXYFLAVONE 3,5,7-TRIHYDROXY-2-(4-HYDROXY-3-METHOXYPHENYL)-4-BENZOPYRONE 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-1-benzopyran-4-one 3,5,7-trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on 3'-METHOXY-3,4',5,7-TETRAHYDROXYFLAVONE 3'-METHOXY-3,5,7,4'-TETRAHYDROXYFLAVONE 3-METHYLQUERCETIN ISOHAMNETIN ISORHAMNETIN 2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on 3,4’,5,7-tetrahydroxy-3’-methoxy-flavon 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-1-benzopyran-4-on 3’-methoxy-3,4’,5,7-tetrahydroxy-flavon 3’-methoxyquercetin c.i.75680 isorhamnetol ISOHAMNETIN:3'-METHOXY-3,4',5,7-TETRAHYDRO-XY-FLAVONE 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxy-phenyl)chromen-4-one QUERCETIN-3-METHYLETHER QUERCETIN-3-ORTHO-METHYLETHER

Chemical Properties

Melting point	307°C
Boiling point	599.4±50.0 °C(Predicted)
density	1.634±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form	neat
pka	6.31±0.40(Predicted)
color	Light yellow to Amber to Dark green
BRN	44723
Stability:	Hygroscopic
InChIKey	IZQSVPBOUDKVDZ-UHFFFAOYSA-N
LogP	1.760 (est)
CAS DataBase Reference	480-19-3(CAS DataBase Reference)

Safety Data

Hazard Codes	Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S22:Do not breathe dust . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . less more
WGK Germany	3
RTECS	LK9275450
HS Code	29329990

Hazard Information

Chemical Properties

Beige to lighet yellow powder

Uses

A metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Uses

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin . It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 μM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 μM), which has an important role in the excretion of xenobiotics at the kidney and liver. It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.

Application

Isorhamnetin is a metabolite of the flavanoid Quercetin with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Definition

ChEBI: A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.

benefits

Isorhamnetin may have potential benefits in inhibiting the onset and treatment of neuroinflammatory diseases. Isorhamnetin is not that much studied than quercetin. However, the few that exist indicate that isorhamnetin has similar health benefits: it may reduce the risk of cancer, improve heart health and ease diabetes complications.

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Biochem/physiol Actions

Isorhamnetin inhibits adipogenesis by interfering with differentiation of adipose stem cells, by a mechanism involving stabilization of β-catenin and up-regulating the Wnt signaling pathway.

storage

Store at -20°C

Questions And Answer

Spectrum Detail

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Chengdu Biopurify Phytochemicals Ltd.

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480-19-3

Chemical Properties

Safety Data

Hazard Information

Chemical Properties

Uses

Uses

Application

Definition

benefits

General Description

Biochem/physiol Actions

storage

Questions And Answer

Description

References

Spectrum Detail

Well-known Reagent Company Product Information

Supplier

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