| Thymopentin Basic information |
| Product Name: | Thymopentin |
| Synonyms: | Thyopentin;Thymopent njection;32-36-Thymopoietin;L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH;Thymopoietin II-(32-36);ThyMopentin for Injection;TP-5;THYMOPENTIN |
| CAS: | 69558-55-0 |
| MF: | C30H49N9O9 |
| MW: | 679.77 |
| EINECS: | 811-641-8 |
| Product Categories: | Inhibitors;IMMUNOX;Amino Acid Derivatives;Peptide |
| Mol File: | 69558-55-0.mol |
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| Thymopentin Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml |
| pka | 3.07±0.10(Predicted) |
| form | Powder |
| color | White |
| CAS DataBase Reference | 69558-55-0(CAS DataBase Reference) |
| WGK Germany | 3 |
| HS Code | 3504009000 |
| Provider | Language |
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| SigmaAldrich | English |
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| Thymopentin Usage And Synthesis |
| Description | Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis. |
| Originator | Janssen (Belgium) |
| Uses | Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide. |
| Uses | immunoregulator |
| Definition | ChEBI: Thymopentin is an oligopeptide. |
| Brand name | SINTOMODULINA; TIMUNOX |
| Clinical Use | Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance. |
| References | Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109. |
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| Thymopentin Preparation Products And Raw materials |
| Raw materials | AMBERLITE(R) IRC-50-->ANION EXCHANGE RESIN 717-->SEPHADEX G-75 |
Product picture
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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In stock
Japan
