| CAS: | 548-04-9 |
| MF: | C30H16O8 |
| MW: | 504.44 |
| EINECS: | 208-941-0 |
| Product Categories: | Nutraceuticals;Antitumour;Natural Plant Extract;Anthraquinones, Hydroquinones and Quinones;antibiotic;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Plant extracts;Herb extract;plant extract |
| Mol File: | 548-04-9.mol |
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| Hypericin Chemical Properties |
| Melting point | 299-301°C |
| Boiling point | 1020.3±65.0 °C(Predicted) |
| density | 1.915±0.06 g/cm3(Predicted) |
| RTECS | SF8472000 |
| storage temp. | -20°C |
| solubility | 1 M NaOH: 10 mg/mL |
| form | powder |
| pka | 6.91±0.20(Predicted) |
| color | black |
| Water Solubility | Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water. |
| Sensitive | Light Sensitive |
| Merck | 14,4863 |
| BRN | 1917913 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | BTXNYTINYBABQR-UHFFFAOYSA-N |
| LogP | 10.827 (est) |
| CAS DataBase Reference | 548-04-9(CAS DataBase Reference) |
| Uses | (1) Antidepressant, increase immunity.
(2) For the treatment of antidepressants, increase immunity. |
| Description | An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC50 = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses. |
| Chemical Properties | Powder |
| Uses | It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method. |
| Definition | ChEBI: Hypericin is a carbopolycyclic compound. It has a role as an antidepressant. It derives from a hydride of a bisanthene. |
| General Description | Produced by HWI Analytik
Exact content can be found on the certificate |
| Biological Activity | Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light. |
| Biochem/physiol Actions | Primary TargetPKC |
| storage | +4°C |
| Purification Methods | Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.] |
| References | 1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm. Des., 11 233 2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol. Pharmacol., 6 1775 |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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