| Name | Hypericin |
| Description | Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities. |
| In vitro | METHODS: Erythrocytes were treated with Bioymifi (10-100 µM) for 24 h. Flow cytometry was used to characterize the hemolytic and bactericidal properties of Bioymifi and the potential molecular mechanisms.
RESULTS: Bioymifi exerted a dose-responsive, calcium-independent hemolytic effect, reduced erythrocyte hemoglobin, and significantly increased membrane-bound protein V, Fluo4, and DCF-positive cells, as well as a dual effect on forward and lateral light scattering. [1]
METHODS: Neonatal rat ventricular myocytes (nrvm) were treated with Bioymifi (10 µM) for 24 h, and the expression levels of target proteins were detected by Western Blot.
RESULTS: The expression of DR5 was higher than that of NRVF in Bioymifi-treated nrvm. [2] |
| In vivo | METHODS: To investigate the role of DR5 activation in the heart, Bioymifi (5 mg/kg/d) micro-osmotic pump was administered to C57BL/6 mice once daily for two weeks.
RESULTS: Bioymifi administration resulted in hypertrophy at the level of cardiac organs and cardiomyocytes, but did not affect cardiomyocyte death or cardiac fibrosis. [2] |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 5 mg/mL (9.91 mM), Heating is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.25 mg/mL (2.48 mM), Solution.
DMSO : 100 mg/mL (198.24 mM), Sonication is recommended.
Propylene glycol : 2.52 mg/mL (5 mM), Sonication is recommended.
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| Keywords | TyrosineKinases | Tyrosine Kinases | tyrosine kinases | telomerase and CYP | Telomerase | Reverse Transcriptase | Protein kinase C | PKC | monoaminoxidase | Monoamine Oxidase | melanocytes | MAO | keratinocytes | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | Hypericum | Hypericin | fibroblasts | Dopamine β-monooxygenase | Dopamine β-hydroxylase | Dopamine beta-monooxygenase | Dopamine beta-hydroxylase | Cytochrome P450 | CYPs | Apoptosis | antiviral activity | antiviral | antitumor activity | antidepressive activity | Antibiotic | antibacterial |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Emtricitabine | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Lamivudine | Dimethyl sulfoxide | Sodium diacetate | BES |
| Related Compound Libraries | Polyphenolic Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | Bioactive Compounds Library Max | TGF-beta/Smad Compound Library | Anti-Cancer Drug Library |
United States
