CAS | 9041-08-1 |
Product name | Heparin sodium |
Einecs number | 232-681-7 |
Quality Standard | BP USP EP IP IH |
Appearance Character | White Powder |
Assay | NLT180IU/MG |
Expiry Date | 24 months |
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Heparin Sodium CAS# 9041-08-1 is a heparin polymer that produces its major anticoagulant effect by activating antithrombin. This activation causes a conformational change in ATIII and allows for increased flexibility in its reactive site loop. Heparin is a highly sulfated glycosaminoglycan known for preventing clots. Heparin, Sodium Salt is also an activator of RyR and ATIII. Heparin sodium is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.Heparin sodium CAS# 9041-08-1 is one of our hot sell products.
Product introduction
Heparin sodium is a naturally occurring glycosaminoglycan that is extracted from animal tissues, primarily porcine intestines or bovine lungs. It is a complex polysaccharide composed of repeating disaccharide units.
Physically, heparin sodium is a white to off-white powder. It is hygroscopic, meaning it has a tendency to absorb moisture from the air. It is soluble in water and forms a clear solution. The solubility in water is an important characteristic as it allows for easy formulation into various pharmaceutical preparations.
Chemically, heparin sodium is negatively charged due to the presence of sulfate and carboxyl groups. This negative charge gives it the ability to interact with positively charged molecules, such as proteins. The molecular weight of heparin sodium can vary depending on the source and extraction method, but it typically ranges from 5, 000 to 30, 000 Daltons.
The main mechanism of action of heparin sodium is through its ability to inhibit blood clotting. It accomplishes this by enhancing the activity of antithrombin III, a natural inhibitor of blood clotting factors. Heparin sodium binds to antithrombin III and causes a conformational change in the protein, which greatly increases its ability to inactivate clotting factors such as thrombin and factor Xa. By inhibiting these clotting factors, heparin sodium prevents the formation of blood clots and helps to maintain the fluidity of blood.
Heparin sodium is widely used in the prevention and treatment of venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). It is often administered to patients who are at high risk of developing blood clots, such as those who have undergone major surgeries, are immobilized for long periods, or have certain medical conditions that increase the risk of clotting.In addition to VTE prevention and treatment, heparin sodium is also used in the management of acute coronary syndromes, such as unstable angina and myocardial infarction. It helps to prevent the formation of new blood clots and reduces the risk of further damage to the heart.Heparin sodium is also used during hemodialysis and other extracorporeal circulation procedures to prevent clotting in the blood tubing and filters.
Heparin sodium has been studied for its potential use in the treatment of certain inflammatory conditions. It is believed that its anti-inflammatory properties may be beneficial in conditions such as sepsis and acute respiratory distress syndrome.It has also been investigated for its role in cancer therapy. Some studies suggest that heparin sodium may have antitumor effects by inhibiting the growth and metastasis of cancer cells.
The most common adverse effects are bleeding and thrombocytopenia. Bleeding can range from minor bruising to more serious bleeding episodes, such as gastrointestinal bleeding or intracranial hemorrhage. Thrombocytopenia is a decrease in the number of platelets in the blood and can increase the risk of bleeding.
Other less common adverse effects include hypersensitivity reactions, osteoporosis, and alopecia. Heparin-induced osteoporosis can occur with long-term use and is more likely in patients who receive high doses or prolonged treatment.
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