Pharmacological action Goserrelin acetate is a synthetic analogue of luteinizing hormone releasing hormone. Long-term use of Goserrelin acetate can inhibit the secretion of luteinizing hormone in the pituitary gland, resulting in the decline of serum testosterone in males and serum estradiol in females. This effect is reversible after withdrawal. In male patients, the testosterone concentration can be reduced to the post-castration level about 21 days after the first dose, and the testosterone concentration remains in the post-castration concentration range during the course of treatment with one dose every 28 days. The testosterone inhibition of goserrelin acetate results in regression of prostate tumors and improvement of symptoms in most patients. Serum estradiol concentrations in women were treated with Chemicalbook suppressant at about 21 days after initial treatment and maintained at postmenopausal levels every 28 days after treatment. This inhibition is associated with hormone-dependent breast cancer, endometriosis. Pharmacokinetic Goserrelin acetate has an almost complete bioavailability. An injection of the implant every 4 weeks can maintain the effective blood concentration without tissue accumulation. In normal renal function, the plasma clearance half-life is 2-4 hours, and the half-life of patients with renal insufficiency will be extended, but for patients who use the implant monthly, this effect is very small, so there is no need to change the dosage of these patients. There was no significant change in pharmacokinetics in patients with hepatic insufficiency.
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