Sex Hormone Drugs

Sex hormones include estrogen, progesterone, androgen, and gonadotrophin. Protein anabolic hormones often have a similar effect with androgens, for which they are usually also listed in the sex hormones. Sex hormones are mainly used for menopausal syndrome, endometriosis and disease caused by sex hormone deficiency. As the long medication use time, the relationship between long-term use of sex hormones and tumorigenesis has caused the public concern. Some data suggests that the long-term use of high-dose estrogen for menopausal syndrome will increase the risk of endometrial cancer, but a small dose or 10 d estrogens per month not. The carcinogenic effects of long-term use of hormonal contraceptives are only obtained in animal experiments, and there are different opinions for clinical application. Recently listed sex hormone drugs either have a stronger role, such as nylestriol, or a broader role, such as tibolone, which show light adverse reactions as a whole. Triptorelin and leuprorelin act on the pituitary hormone-releasing hormone, resulting in the short-term increase in LH and FSH and the sex hormone inhibition. With the development of IVF technology, ovulation control drugs have drew more people’s attention, and Cetrorelix in clinical application has been successful.

---