Target Paracellularpermeability in vitro studies (ZO - 1) andacti Larazotideacetateinhibitstheredistributionandrearrangementofzonulaoccludens - 1 ncausedbyAT-1002andgliadinfragmentsinCaco-2andIEC6cells.LarazotideacetateinhibitstheAT-1002-inducedTEERreductionandTJope ninginCaco-Chemicalbook2cells.Larazotideacetateinhibitsthetranslocationofagliadin13-merpeptide,whichhasbeenimplicatedinc eliacdisease,acrossCaco-2cellmonolayers.Further,apicallyappliedLarazotideacetateinhibitstheincreaseinTJpermeabilityelici tedbybasolaterallyappliedcytokines.
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