Goserelin acetate

CAS: 145781-92-6

MF: C59H84N18O14

MW: 1269.41

EINECS: 652-995-1

Melting point >190°C (dec.)

storage temp. −20°C

solubility H2O: 20 mg/mL, clear, colorless

form white powder

Goserelin acetate, like leuprolide acetate, is a synthetic superagonist nonapeptide analogue of GnRH that possesses greater potency than the natural hormone. Note that it contains D-Ser(But) and NH-NHCONH2 in place of Gly6 and Gly10-NH2, respectively. That is, the C terminal modification simply has an NH substituting for the CH2 of Gly, and like the C-terminal change in leuprolide acetate, this inhibits enzymatic degradation of the peptide by the postproline carboxyamide peptidase.