Climbazole
Cas NO.: 38083-17-9 ，
Molecular Formula: C15H17ClN2O2
Molecular Mass：292.7607
HPLC： 99%
Climbazole has shown high anti-Pityrosporum ovale efficacy both in vivo and in vitro,
and Pityrosporum ovale may be the main cause of dandruff.
Pityrosporum ovale may be the main cause of dandruff.
What is Climbazole and How is it Used in Cosmetic Products?
Climbazole is an additive and antifungal agent used in over-the-counter shampoos, conditioners,
lotions,hair care, soap, shower gel, medicated toothpaste, mouthwash and other high-grade detergents.
, and face washes to treat human fungal skin infections like eczema and dandruff.
Dandruff is suffered by as much as half of the population and about one in every ten individuals
in the United States will develop eczema during their lifetime. This agent helps to treat these
moderate to severe fungal infections and their symptoms such as redness, and dry, itchy, and flakey
skin without causing irritation to the affected area when used properly.
Is Climbazole Safe?
In the use of cosmetic products with a maximum concentration of 0.5% Climbazole cannot be
considered safe, but when it is used as a preservative in hair cosmetics and face cosmetics at 0.5%,
it does not pose a risk to the health of the consumer. Climbazole is a stable acid with a neutral pH
that ranges between pH 4-7 and has excellent light, heat and storage abilities.
Is Climbazole more Effective when Combined with Zinc Pyrithione for Dandruff?
Though Climbazole is effective on its own, the addition of zinc pryithione can add to the shampoo’s
efficacy. Zinc pyrthione can inhibit the growth of yeast, which is a main factor in dandruff, and has
antibacterial, antimicrobial, and anti-fungal properties that can work in conjunction with Climbazole.
How do you Dissolve Climbazole?
Climbazole is soluble and can be dissolved in a small amount of rubbing alcohol, glycols, surfactants,
and perfume oils, but it is insoluble in water. It also dissolves faster at elevated temperatures so
using a warm solvent is recommended.
Is Dandruff a Fungus?
Most dandruff problems are a result of fungus known as Malassezia that live on your scalp causing
skin cells to multiply more quickly than usual. The most effective treatment is dandruff shampoo
that delivers the anti-fungal agent directly to the scalp.
Is Eczema a Fungus?
Eczema, also known as eczematous dermatitis, has many causes such as predetermined genetic
allergens, but the most common is a bacterium know as Staphylococcus aureus.
This is found on the skin of almost everyone who suffers from eczema since it thrives on the weepy,
broken skin caused by this condition. It can also provide entry points for infection making
treatment even more difficult. Though eczema is normally not a fungus itself, inhibiting
infection using an anti-fungal agent such as Climbazole can be the key to successful treatment
of eczema.
Why is Climbazole use Restricted in the EU?
In May 2019, the European Commission restricted the use of Climbazole in cosmetics.
This restriction allows up to an authorized concentration of 0.5% in a finished product when used
as a preservative and 2% in rinse-off shampoos when used as an anti-dandruff agent.
This regulation was published to protect those in an aggregate exposure scenario while considering
the safe concentration levels of Climbazole at 0.2% in face creams, hair lotion, and foot creams
and at 0.5% in rinse-off shampoos.
How can Chem Service help in the Testing for Climbazole?
Over exposure of Climbazole can cause irritation of the skin including redness, rashes, itching
and allergic reactions. Use Chem Service for our years of experience in testing chemical quality
and quantities. Click over to the Chem Serve Climbazole web page to learn more or call our
seasoned staff at 1-800-452-9994 to discuss how we can best serve your needs.
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