Acetaminophen is an acetanilid antipyretic analgesic. By inhibiting cyclooxygenase, selectively inhibiting the synthesis of prostaglandin in the hypothalamic body temperature regulation center, leading to peripheral vasodilation and sweating to achieve antipyretic effect, the intensity of antipyretic effect is similar to aspirin; by inhibiting the synthesis of prostaglandins, etc. And release, increase the pain threshold and play an analgesic role, which belongs to peripheral analgesics, the effect is weaker than aspirin, only effective for mild to moderate pain.
| Standard | BP2017/USP40 |
| Tests | Specification | Results |
| Characters | Appearance: A White or almost white crystalline powder Solubility: Sparingly soluble in water, freely soluble in alcohol, very slightly soluble in methylene chloride. | Conforms
Conforms |
| Identification | Mp | 168ºC~172ºC | 169.7ºC~170.1ºC |
| IR | Consistent with the spectrum of paracetamol CRS | Conforms |
| Loss on drying | <0.5% | 0.05% |
| Sulphated ash | <0.1% | 0.04% |
| Heavy Metals | <20ppm | < 20ppm |
| Related substances | Impurity J | (4-Chloroacetanilide) <10 ppm | < 10ppm |
| Impurity K | (4-Aminophenol )<50ppm | < 50ppm |
| Impurity F | (4-nitrophenol)<0.05% | < 0.05% |
| Any other impurity | <0.05% | < 0.05% |
Total of
other impurities | <0.1%
- | < 0.1% |
| Assay | 99.0%-101.0% | 99. 30% |
| Conclusion: It complies with the requirements of BP2017/USP40 ' . |
Hebei Jingbo New Material Technology Co., Ltd. was founded in 2007 , located in Shijiazhuang city which is the capital of Hebei Province and hub sector among Beijing Tianjin and Hebei and has advantage of convenient transportation . Our company is a modern high-tech chemical enterprise with Research & Development, production and sales.Our company has strong technical strength, advanced equipment, strict quality management system and high-quality after-sales service, adhers to the "customer first and forge ahead" business philosophy and insists on integrity as the company's survival.
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