| Name | Ac-YVAD-CMK |
| Description | Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity. |
| In vitro | Ac-YVAD-cmk (40 and 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia[3]. |
| In vivo | In SD rats, Ac-YVAD-cmk treatment (1 μg; injection into the left lateral ventricle) significantly decreases the protein levels of caspase-1 and mature IL-1β/IL-18 compared with the ICH group[3]. Ac-YVAD-cmk (12.5 μmol/kg) significantly reduces mortality from 83 to 33% in rats[4]. |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (166.4 mM), Sonication is recommended. DMF : 10 mg/mL (18.48 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.1 mM), Sonication is recommended.
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| Keywords | Pyroptosis | Inflammationrelated | Inflammation related | inflammation | Immunologyrelated | Immunology related | ILReceptor | IL-1β | IL Receptor | Caspase-1 | Ac-YVAD-CMK |
| Inhibitors Related | Benzyl cinnamate | Inosine pranobex | Amlexanox | Dexamethasone acetate | L-Arginine | Dexamethasone | (Iso)-Z-VAD(OMe)-FMK | α-Terpineol | Tauroursodeoxycholate | Diallyl disulfide | Linalool | Apilimod |
| Related Compound Libraries | Apoptosis Compound Library | Cysteine Covalent Library | Bioactive Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |