ChemicalBook CAS DataBase List 178603-78-6

178603-78-6

Name	AC-YVAD-CMK
CAS	178603-78-6
Molecular Formula	C24H33ClN4O8
MDL Number	MFCD00237124
Molecular Weight	540.99
MOL File	178603-78-6.mol

Chemical Properties

Melting point	>205°C (dec.)
RTECS	AY3079566
storage temp.	-20°C
solubility	DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
form	White solid
color	white to off-white
Stability:	Hygroscopic
InChIKey	CQZPAKWASFYDKD-DGJUNBOTSA-N
SMILES	C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(C)=O)[C@@H](CC(O)=O)C(=O)CCl

Safety Data

WGK Germany

Hazard Information

Uses

Ac-YVAD-cmk has been used:

as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
as a caspase-1 inhibitor injected to C57BL/6 mice
as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition

Uses

Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]

General Description

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Biochem/physiol Actions

Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.

in vivo

Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group^[2].
Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis^[3].

IC 50

Caspase-1

storage

Store at -20°C

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