| Name | Ac-FLTD-CMK |
| Description | Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7 nM, 1.49 μM and 329 nM, respectively. Ac-FLTD-CMK showed potency against caspases-1, caspases-4 and caspases-11, but not against apoptosis-associated caspase-3. |
| In vitro | Ac-FLTD-CMK, inhibits GSDMD cleavage by caspases-1, -4, -5, and -11 in vitro, suppresses pyroptosis downstream of both canonical and noncanonical inflammasomes, as well as reduces IL-1β release following activation of the NLRP3 inflammasome in macrophages. By contrast, Ac-FLTD-CMK does not target caspase-3 or apoptotic cell death. Crystal structure of caspase-1 in complex with Ac-FLTD-CMK reveals extensive enzyme-inhibitor interactions involving both hydrogen bonds and hydrophobic contacts.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (5.8 mM), Sonication is recommended.
DMSO : 90.0 mg/mL (158.2 mM), Sonication is recommended.
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| Keywords | caspase-4 | caspase-11 | caspase-1 | Ac-FLTD-CMK | AcFLTDCMK | Ac FLTD CMK |
| Inhibitors Related | Disulfiram | 10-Hydroxydecanoic Acid | Ascorbyl palmitate | Hydralazine hydrochloride | Ethyl pyruvate | Berberine hydrogen sulphate | Cystamine dihydrochloride | (Iso)-Z-VAD(OMe)-FMK | Benzbromarone | Tauroursodeoxycholate | Berberine sulfate | Cinchonine |
| Related Compound Libraries | Apoptosis Compound Library | Cysteine Covalent Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
United States
