ChemicalBook Product Catalog API Antibiotics Tetracycline drugs Oxytetracyclinehydrochloride

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Oxytetracyclinehydrochloride

$ 1.00 /1KG

Min. Order1KG
Purity99%
Cas No2058-46-0
Supply AbilityKG/T
Update time2019-12-20

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Chemical Properties

Product Name	Oxytetracyclinehydrochloride
CAS No	2058-46-0
EC-No	218-161-2
Min. Order	1KG
Purity	99%
Supply Ability	KG/T
Release date	2019/12/20

heidi59

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Product Name:

Oxytetracycline hydrochloride

Synonyms:

Pharmaceutical Raw Powder Oxytetracycline Hydrochloride / Oxytetracycline HCl;hydrocyclin;liquamycininjectable;mepatar;nsc9169;5-hydroxytetracycline hydrochloride;[4s-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride;GEOMYCIN

CAS:

2058-46-0

MF:

C22H25ClN2O9

MW:

496.89

EINECS:

218-161-2

Product Categories:

Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;L - ZEPA;NeatsAntibiotics;TetracyclinesMore...Close...;1694 Pharmaceuticals&Personal Care Products;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Chemical Structure Class;-;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;Mechanism of Action;Pharmaceutical intermediate

Mol File:

2058-46-0.mol

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Oxytetracycline hydrochloride Chemical Properties

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Melting point

180°C

alpha

-188～-200°(D/20℃)(c=1,0.1mol/l HCl) (calculated on the dried basis)

storage temp.

0-6°C

solubility

Freely soluble in water, sparingly soluble in ethanol (96 per cent). Solutions in water become turbid on standing, owing to the precipitation of oxytetracycline.

form

crystalline

color

yellow

2.0～3.0 (10g/l, 25℃)

Water Solubility

>100 g/L

λmax

360nm(H2O)(lit.)

Sensitive

Light Sensitive

Merck

14,6976

BRN

3853107

CAS DataBase Reference

2058-46-0(CAS DataBase Reference)

EPA Substance Registry System

Oxytetracycline hydrochloride (2058-46-0)

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Oxytetracycline hydrochloride Usage And Synthesis

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Chemical Properties

Yellow Crystalline Solid

Uses

Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial

Uses

Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Brand name

Terramycin (Pfizer).

General Description

Early in 1950, Finlay et al.182 reported the isolation of oxytetracycline(Terramycin) from S. rimosus. This compoundwas soon identified as a chemical analog of chlortetracycline that showed similar antibiotic properties. The structureof oxytetracycline was elucidated by Hochstein et al.183 andthis work provided the basis for the confirmation of thestructure of the other tetracyclines.
Oxytetracycline hydrochloride is a pale yellow, bitter,crystalline compound. The amphoteric base is only slightlysoluble in water and slightly soluble in alcohol. It is odorlessand stable in air but darkens on exposure to strong sunlight.The hydrochloride salt is a stable yellow powder that ismore bitter than the free base. It is much more soluble inwater, 1 g dissolving in 2 mL, and more soluble in alcoholthan the free base. Both compounds are inactivated rapidlyby alkali hydroxides and by acid solutions below pH 2. Bothforms of oxytetracycline are absorbed rapidly and equallywell from the digestive tract, so the only real advantage thefree base offers over the hydrochloride salt is that it is lessbitter. Oxytetracycline hydrochloride is also used for parenteraladministration (intravenously and intramuscularly).

General Description

Odorless fluffy yellow solid or yellow powder. Bitter taste.

Air & Water Reactions

Oxytetracycline hydrochloride is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing.

Reactivity Profile

Oxytetracycline hydrochloride is sensitive to light. Oxytetracycline hydrochloride may be unstable at temperatures above 77° F. Oxytetracycline hydrochloride darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Oxytetracycline hydrochloride undergoes hydrolysis in the presence of water. Oxytetracycline hydrochloride may be incompatible with alkalis.

Fire Hazard

Flash point data for Oxytetracycline hydrochloride are not available. Oxytetracycline hydrochloride is probably combustible.

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