| Name | Oxytetracycline Hydrochloride |
| Description | Oxytetracycline Hydrochloride (Dalimycin) is a tetracycline derivative produced by Streptomyces rimosus with antimicrobial activity. It interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, resulting in preventing peptide elongation and inhibiting protein synthesis. |
| In vivo | The 10-day effect of oxytetracycline at therapeutic doses (82.8 mg/kg bw to 1 % bw/day) was species-specific. Oxytetracycline increases the enzymatic activity of CYP3A4 in Ictalurus punctatus, increases the protein expression of CYP3A4 in Oreochromis niloticus, and depletes hepatic CYP3A4 in the latter, and also increases the relative liver weight of Morone chrysops x M. saxatilis [1]. Oxytetracycline is limited to 100 μg/kg in muscle and breast milk, 200 μg/kg in eggs, 300 μg/kg in liver, and 600 μg/kg in kidney[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : Insoluble
DMSO : 60 mg/mL (120.75 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (8.05 mM), Sonication is recommended.
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| Keywords | tetracycline | synthesis | protein | Oxytetracycline Hydrochloride | Oxytetracycline | m-ribosomal | Inhibitor | inhibit | Human Endogenous Metabolite | HSV-1 | HSV | Herpes simplex virus | Gram-positive | Gram-negative | EndogenousMetabolite | Endogenous Metabolite | Bacterial | Antiviral | Antibiotic | Antibacterial | aminoacil-tRNA |
| Inhibitors Related | Sucrose | Neomycin sulfate | Aceglutamide | Emtricitabine | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Glycerol | Thymidine | Sodium 2-hydroxybutanoate | BES |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Viral Compound Library | Microbial Natural Product Library | Anti-Bacterial Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Human Metabolite Library |
United States
