General Description
Odorless fluffy yellow solid or yellow powder. Bitter taste.
Reactivity Profile
OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) is sensitive to light. OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) may be unstable at temperatures above 77° F. OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. This chemical undergoes hydrolysis in the presence of water. OXYTETRACYCLINE HYDROCHLORIDE(2058-46-0) may be incompatible with alkalis.
Air & Water Reactions
This chemical is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing.
Fire Hazard
Flash point data for this chemical are not available. OXYTETRACYCLINE HYDROCHLORIDE is probably combustible.
Description
Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). Oxytetracycline hydrochloride is used to study phagosome-lysosome (P-L) fusion in P388D1 cells and antibiotic susceptibilities of Mycoplasma bovis isolates.
Chemical Properties
Yellow Crystalline Solid
Originator
Terramycin,Pfizer,US,1950
Uses
Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial
Uses
Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
Definition
ChEBI: Oxytetracycline hydrochloride is an organic molecular entity.
Manufacturing Process
The pH was adjusted to 7.0 with sodium hydroxide and calcium carbonate was added at the rate of 1 g/l.
500 ml portions of the above medium were added to Fernbach flasks which
were then sterilized at 121°C for 30 minutes. Upon cooling, the flasks were inoculated with a suspension of the growth of s. rimosus obtained from the surface of beef lactose agar slants, and the flasks were shaken for 4 days at 28°C on a rotary shaker having a displacement of 2" at an rpm of 200. At the end of this period the broth was found to contain 640 C.D.U/ml and 400 chloramphenicol units/ml. The mycelium was separated from the broth by filtration and the latter was adjusted to pH 9.0. The antibiotic was extracted from the broth with n-butanol, and when the ultraviolet absorption spectrum was observed on the butanol solution of the antibiotic, peaks in the absorption curve were found at 385 and 270 millimicrons.
Brand name
Terramycin (Pfizer).
Therapeutic Function
Antibiotic
