An alkaloid present in Sophora alopecuroides, the base possesses the tetracyclic
structure characteristic of the Sophora alkaloids. It is 1aevorotatory with [α]D -
90.85° or - 98° (EtOH). It yields a series of well crystalline salts and derivatives
including the hydrochloride, m.p. 247-8° (dec.); hydriodide, m.p. 294-6°C;
aurichloride, m.p. 183-4°C (dec.); p1atinich1oride, m.p. 245-7°C (dec.); picrate,
m.p. 229-231°C (dec.) and the picrolonate, m.p. 173-5°C (dec.).
Sophoramine is a quinolizidine alkaloid isolated from traditional Chinese herbal drugssuch as Sophora flavescens Ait. (Kushen), S. alopecuroides L. (Kudouzi or Kugancao) and S. tonkinensis Gapnep (Shandougen).
ChEBI: Sophoramine is a naphthyridine derivative.
Orekhov., Chern. Zentr., II, 2215 (1935)
Orekhov, Proskurnina, Konovalova., Ber., 68,431 (1935)
Proskurnina, Kuzovkov., Dokl. Akad. Nauk SSSR, 91, 1145 (1953)
Okuda et al., Chern. & Ind., 1326 (1962)
