Description
An alkaloid present in Sophora alopecuroides, the base possesses the tetracyclic
structure characteristic of the Sophora alkaloids. It is 1aevorotatory with [α]
D -
90.85° or - 98° (EtOH). It yields a series of well crystalline salts and derivatives
including the hydrochloride, m.p. 247-8° (dec.); hydriodide, m.p. 294-6°C;
aurichloride, m.p. 183-4°C (dec.); p1atinich1oride, m.p. 245-7°C (dec.); picrate,
m.p. 229-231°C (dec.) and the picrolonate, m.p. 173-5°C (dec.).
Uses
Sophoramine is a quinolizidine alkaloid isolated from traditional Chinese herbal drugssuch as Sophora flavescens Ait. (Kushen), S. alopecuroides L. (Kudouzi or Kugancao) and S. tonkinensis Gapnep (Shandougen).
References
Orekhov., Chern. Zentr., II, 2215 (1935)
Orekhov, Proskurnina, Konovalova., Ber., 68,431 (1935)
Proskurnina, Kuzovkov., Dokl. Akad. Nauk SSSR, 91, 1145 (1953)
Okuda et al., Chern. & Ind., 1326 (1962)
