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PROMETHAZINE Basic information
PROMETHAZINE Chemical Properties
  • Melting point:60℃
  • Boiling point:bp3 190-192°
  • Density 1.131
  • refractive index 1.6000 (estimate)
  • pkapKa 9.1(H2O,t undefined) (Uncertain)
  • Water Solubility 383.9ug/L(22.5 ºC)
  • EPA Substance Registry SystemPromethazine (60-87-7)
Safety Information
  • ToxicityLD50 oral in rabbit: 580mg/kg
PROMETHAZINE Usage And Synthesis
  • UsesAnti-emetic; antihistaminic.
  • DefinitionChEBI: A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.
  • brand namePhenergan (Wyeth).
  • World Health Organization (WHO)Introduced in 1946, promethazine, a phenothiazine derivative has a variety of pharmacological properties. At present it is mainly used as an antihistamine and anti-motion-sickness drug. Promethazine is listed in the WHO Model List of Essential Drugs.
  • General DescriptionCrystals. Melting point 60°C. Used as an antihistaminic.
  • Air & Water ReactionsTurns blue on prolonged exposure to air and moisture.
  • Reactivity ProfilePROMETHAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable or toxic gases may be generated in combination with strong reducing agents, such as hydrides.
  • Health HazardSYMPTOMS: Symptoms of PROMETHAZINE include leucopenia; agranulocytosis; confusion; convulsions; stupor; and it potentiates the action of central nervous system depressants.
  • Fire HazardFlash point data for PROMETHAZINE are not available, however PROMETHAZINE is probably combustible.
  • Safety ProfilePoison by ingestion, intravenous, intramuscular, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: pupillary dilation, wakefulness, hallucinations, and distorted perceptions. An experimental teratogen. Other experimental reproductive effectsHuman mutation data reported. A severe eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx
PROMETHAZINE Preparation Products And Raw materials
PROMETHAZINE(60-87-7)Related Product Information
  • Company Name:Syntechem Co.,Ltd
  • Tel:Please Email
  • Company Name:Hangzhou Yuhao Chemical Technology Co., Ltd
  • Tel:0571-82693216
  • Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
  • Tel:18927568969 020-39119399-
  • Company Name:Shanghai TaoShu Biochemical Technology Co., Ltd.
  • Tel:18019718960 021-33632979
  • Company Name:HangZhou YuHao Chemical Technology Co., Ltd.
  • Tel:0571-82693216