propiomazine

Product Namepropiomazine
CAS362-29-8
MFC20H24N2OS
MW340.48
EINECS206-646-1
MOL File362-29-8.mol

Chemical Properties

Boiling point	bp0.5 235-245°
Density	1.137±0.06 g/cm3(Predicted)
pka	pKa 6.6(H2O) (Uncertain)

Safety Information

Hazardous Substances Data

362-29-8(Hazardous Substances Data)

Usage And Synthesis

Uses

1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.

Uses

Propiomazine is used in the preparation of analgesics as well as maintaining its own analgesic effects whilst applied to various neurological diseases.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2.

brand name

Largon (Baxter Healthcare).

in vivo

Propiomazine (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations^[3].
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl₄-induced hepatic injury^[4].
Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats^[5].