A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro
It is a representative metabolite derived by the oxidation of Guanosine (G) and is regarded as a marker of oxidative stress in the cells.
ChEBI: 8-Hydroxyguanosine is a purine nucleoside.
Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
8-Hydroxyguanosine (60 mg/kg, i.p., 4 h before LPS (1 mg/kg) injected) attenuates the LPS-induced increase in serum levels of TNF-α and IL-18 in LPS-treated mice[4].
| Animal Model: | LPS-treated mice[4] |
| Dosage: | 60 mg/kg |
| Administration: | i.p., 4 h before LPS (1 mg/kg) injected |
| Result: | Attenuated the LPS-induced increase in serum levels of TNF-α and IL-18, but was not significant for IL-6 and IL-12p70 in mice. |
Human Endogenous Metabolite
