8-Aminoguanosine, a guanosine derivative, is an orally available and highly efficacious potassium-sparing diuretic/natriuretic th at increased sodium excretion by 26.2-fold and decrease potassium excretion by 69.1%. 8-Aminoguanosine increases glucose excretion by 12.2-fold. Also 8-Aminoguanosine suppressed deoxycorticosterone/salt-induced hypertension.', '8-Aminoguanosine is known to stimulate diuresis, natriuresis, glucosuria and antikaliuresis. It is an analog of guanosine, th at can block purine nucleoside phosphorylase, in vitro and in intact lymphoid cells. 8-aminoguanosine triphosphate can be used to block GTP (guanosine triphosphate) cyclohydrolase I from human liver and Escherichia coli.
