ChemicalBook > Product Catalog > Biochemical Engineering > Nucleoside drugs > Nucleotides and their analogs > URIC ACID
URIC ACID Chemical Properties
- Melting point:>300 °C(lit.)
- Boiling point:297.02°C (rough estimate)
- Density 1,9 g/cm3
- refractive index 1.9900 (estimate)
- storage temp. Store at RT.
- pka3.89(at 12℃)
- form crystalline
- color White to off-white
- Water Solubility Soluble in 1M sodium hydroxide solution. Slightly soluble in water. Insoluble in ether and alcohol.
- Merck 14,9875
- BRN 156158
- Stability:Stable. Incompatible with acids, bases, oxidising agents.
- CAS DataBase Reference69-93-2(CAS DataBase Reference)
- EPA Substance Registry SystemUric acid (69-93-2)
URIC ACID Usage And Synthesis
- IntroductionUric acid is a breakdown substance of purines which exist in body tissues and some food and drinks. Purines are a type of chemical compound in nature consisted in nucleic acids (DNA and RNA). Uric acid is created in the body via purine metabolism and circulated within the bloodstream, and it will be excreted in urine as waste. As a result, there is a certain balanced amount of uric acid in the bloodstream, which is of great importance to the functions of body.
Uric acid is composed in the form of urate of ammonia, and it is the primary constituent of the urine of birds and reptiles. Uric acid helps to keep the birds' weight down which is crucial for their flight. Due to its acidic properties, uric acid from birds does damage paints on cars. Insects produce uric acid during protein catabolism. In addition, uric acid helps to make butterflies iridescent. Its crystals also reflect the light produced in fireflies by bioluminescence.
- Properties and PreparationUric acid is a colorless, odorless and tasteless solid with molecular formula C5H4N4O3. It is largely insoluble in water (60 mg/L, at 20 °C). It is soluble in 1 M NaOH (50 mg/ml). Rather than melt, it decomposes in air above 250°C.
Uric acid is produced from purines by the enzyme xanthine oxidase via the purine metabolism pathway. In the majority of mammals, uric acid is further degraded to allantoin via the urate oxidase (uricase) enzyme. Allantoin is then freely excreted from the body in the urine. Humans, apes, and certain New World monkeys have higher uric acid levels compared with other mammals. Commercially, uric acid has been prepared from guano, which is essentially the droppings of bats or seabirds. Large quantities of guano can be found on some islands. Uric acid can be produced via extracting guano with alkali and then precipitating with acid.
- Chemical PropertiesUric acid, (C5H4O3N4) is a white solid, insoluble in cold water, alcohol or ether, sparingly soluble in hot water. Uric acid is a weak dibasic acid thus forming two series of salts, most of which are very slightly soluble in water (lithium urate soluble).
- OccurrenceUric acid is found in the urine, blood, and muscle juices of carnivorous animals (herbivorous animals secrete hippuric acid), in the excrement of birds, serpents and insects, and is an oxidation product of the complex nitrogenous compounds of the animal organism.
- DefinitionA nitrogen compound produced from purines. In certain animals (e.g. birds and reptiles), it is the main excretory product resulting from breakdown of amino acids. In humans, uric acid crystals in the joints are the cause of gout.
- Definitionuric acid: The end product of purinebreakdown in most primates, birds,terrestrial reptiles, and insects andalso (except in primates) the majorform in which metabolic nitrogen isexcreted. Being fairly insoluble, uricacid can be expelled in solid form,which conserves valuable water inarid environments. The accumulationof uric acid in the synovial ?uidof joints causes gout.
- Safety ProfileExperimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
- Purification MethodsCrystallise uric acid from hot distilled H2O (the solubility in H2O is 1part/39,000parts at 18o and 1part/2,000parts at 100o). It is best purified by dissolving in an alkaline solution and acidifying with dilute HCl and drying it at 100o in a vacuum. [Bergmann & Dikstein J Am Chem Soc 77 691 1955, Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp256-257 1971, ISBN 0-471-38205-1, Beilstein 26 H 513, 26 I 151, 26 II 293, 26 III/IV 2619.]
URIC ACID Preparation Products And Raw materials
- Preparation ProductsCaffeine
- Uric Acid Rabbit Polyclonal Uric Acid (1.00817) 7-METHYL-3-(TRIDEUTEROMETHYL)URIC ACID 7-METHYLURIC ACID 9-METHYLURIC ACID 1,9-DIMETHYL-2,6,8-TRIHYDROXYPURINE [7-CD3]-1,3,7-Trimethyluric Acid 3,7-DIMETHYL-2,6,8-TRIHYDROXYPURINE 3-METHYLURIC ACID URIC ACID, AMMONIUM SALT 7,9-dihydro-3,9-dimethyl-1H-purine-2,6,8(3H)-trione URIC ACID URIC ACID (1,3-15N2),URIC ACID-13-15N2 99%,URIC ACID-1,3-15N2, 99 ATOM % 15N URIC ACID, [8-14C] 7,9-dihydro-3,7,9-trimethyl-1H-purine-2,6,8(3H)-trione 1,7-DIMETHYLURIC ACID 7,9-dihydro-7,9-dimethyl-1H-purine-2,6,8(3H)-trione 7-Methyl-3-(methyl-d3)uric Acid
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