米诺地尔硫酸盐
米诺地尔硫酸盐 性质
| 熔点 | 175-180°C |
|---|---|
| 密度 | 1.75±0.1 g/cm3(Predicted) |
| RTECS号 | UV6260494 |
| 储存条件 | -20°C |
| 溶解度 | 可溶于丙酮（少许）、DMSO（少许） |
| 形态 | 白色固体。 |
| 酸度系数(pKa) | -4.99±0.18(Predicted) |
| 颜色 | 白色至类白色 |
| 稳定性 | 光敏性-避光，储存在冰箱中 |
| InChI | InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17) |
| InChIKey | AGMYAAIWWVATKU-UHFFFAOYSA-N |
| SMILES | C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1 |
| CAS 数据库 | 83701-22-8(CAS DataBase Reference) |
米诺地尔硫酸盐 用途与合成方法
IC50: K channel
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Western Blot Analysis
| Cell Line: | Rat brain microvascular endothelial cells (RBMECs) |
| Concentration: | 0-100 μM |
| Incubation Time: | 15 mins, 30 mins, 1 hour, 2 hours, 4 hours |
| Result: | Induced RhoA activation and PKB phosphorylation at Ser-473. |
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14μM) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.
安全信息
| 危险品标志 | Xn,T+ |
|---|---|
| 危险类别码 | 22-36/37/38-26/27/28 |
| 安全说明 | 26-36-45-36/37/39-22 |
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
米诺地尔硫酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-B1445 | 米诺地尔硫酸盐 | 83701-22-8 | 25 mg | 750 |
| 2025-12-22 | HY-B1445 | 米诺地尔硫酸盐 | 83701-22-8 | 10mM * 1mLin DMSO | 825 |
