米诺地尔硫酸盐

用途生物活性靶点体外研究米诺地尔硫酸盐试剂级价格

米诺地尔硫酸盐

CAS号:83701-22-8
英文名:Minoxidil sulphate
中文名:米诺地尔硫酸盐
CBNumber:CB9494019
分子式:C9H15N5O4S
分子量:289.31
MOL File:83701-22-8.mol

米诺地尔硫酸盐化学性质

熔点 :175-180°C
密度 :1.75±0.1 g/cm3(Predicted)
RTECS号 :UV6260494
储存条件 :-20°C
溶解度 :Acetone (Slightly), DMSO (Slightly)
形态 :White solid.
酸度系数(pKa) :-4.99±0.18(Predicted)
颜色 :White to Off-White
稳定性 :Light Sensitive - Protect from Light, Store in Freezer
InChI :InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
InChIKey :AGMYAAIWWVATKU-UHFFFAOYSA-N
SMILES :C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1
CAS 数据库 :83701-22-8(CAS DataBase Reference)

安全信息

危险品标志 :Xn,T+
危险类别码 :22-36/37/38-26/27/28
安全说明 :26-36-45-36/37/39-22
WGK Germany :3

米诺地尔硫酸盐性质、用途与生产工艺

用途米诺地尔硫酸盐为白色结晶性粉末，可用作降压药，生发剂医药中间体。
生物活性 Minoxidil sulfate 是一种有效的 ATP 敏感的 K+ 通道 (K+ channel) 激动剂，是米诺地尔的硫酸代谢物。Minoxidil sulfate 被认为是一种血管扩张试剂，在动物实验模型中，促进头发生长。
靶点

IC50: K channel

体外研究

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.

Western Blot Analysis

Cell Line:	Rat brain microvascular endothelial cells (RBMECs)
Concentration:	0-100 μM
Incubation Time:	15 mins, 30 mins, 1 hour, 2 hours, 4 hours
Result:	Induced RhoA activation and PKB phosphorylation at Ser-473.

用途
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14μM) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.