2,2-Diethoxyethylamine

There are two main methods of synthesizing aminoacetaldehyde diethyl acetal as follows:

(1) 2-(2-azidoethyl)-1,3-dioxolane is generated from 2-(2-azidoethyl)-1,3-dioxolane by refluxing 2-(2-azidoethyl)-1,3-dioxolane with sodium azide over a phase transfer catalyst, which is further reacted with triphenylphosphine/water, but the NaN3 compounds are highly poisonous and explosive, which is not conducive to industrialized production.

(2) 2-(2-bromoethyl)-1,3-dioxolane is obtained by ion exchange with a macroporous quaternary ammonium Amberlite resin ( AmberliteIRA 900) that has been attached to a negative nitrite ion to obtain 2-(2-nitrosoethyl)-1,3-dioxolane, which is then catalyzed by platinum oxidation to obtain aminoglycolaldehyde diethyl acetal by platinum oxidation catalyst, which has a low yield.