Eprazinone dihydrochloride

Mucitux,Riom,France,1969

Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.

ChEBI: A hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid.

61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.

Antitussive