Basic information Identification Description Regulatory Status Usage Natural occurrence Safety Related Supplier
ChemicalBook >  Product Catalog >  Flavors and fragrances >  Synthetic fragrances >  Oxygen-containing heterocyclic compounds >  Thiazole, thiophene, and pyridine >  3-Acetylpyridine

3-Acetylpyridine

Basic information Identification Description Regulatory Status Usage Natural occurrence Safety Related Supplier
3-Acetylpyridine Basic information
3-Acetylpyridine Chemical Properties
Safety Information
  • Hazard Codes T,Xi,Xn
  • Risk Statements 25-36/38-36/37/38-20/21/22
  • Safety Statements 45-37/39-28A-26-36
  • RIDADR UN 2810 6.1/PG 3
  • WGK Germany 3
  • RTECS OB5425000
  • 8-10
  • Hazard Note Irritant
  • TSCA Yes
  • HazardClass 6.1
  • PackingGroup II
  • HS Code 29333999
  • ToxicityLD50 orl-rat: 46 mg/kg JACTDZ 1,681,92
MSDS
3-Acetylpyridine Usage And Synthesis
  • Identification
    CAS.No.: 
    350-03-8 
    FL.No.: 
    14.039
    FEMA.No.: 
    3424
    NAS.No.: 
    3424
    CoE.No.: 
    2316
    EINECS.No.: 
    206-496-7 
    JECFA.No.: 
    1316
     
     
  • DescriptionA colorless liquid with sweet, nutty, popcorn-like aroma.
  • Regulatory StatusCoE: Used provisionally. Bev.: 2 ppm; Food: 3 ppm
    FDA: n/a
    FDA (other): n/a
    JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2004).
  • UsageReported uses (ppm): (FEMA, 1994)
    Food Category 
    Usual 
    Max. 
    Baked goods 
    2
    3
    Frozen dairy 
    1
    2
    Gelatins,puddings 
    1
    2
    Nonalcoholic beverages 
    1
    2
    Soft candy 
    2
    3
  • Natural occurrenceReported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
  • Chemical Propertiesclear colorless to yellow liquid
  • Chemical PropertiesA colorless liquid with sweet, nutty, popcorn-like aroma
  • OccurrenceReported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.
  • PreparationDry distillation of calcium nicotinate with calcium acetate.
  • DefinitionIt is a nicotinic acidantagonist.
  • Safety ProfilePoison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONES
  • Purification MethodsIt is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]
3-Acetylpyridine Preparation Products And Raw materials
3-Acetylpyridine(350-03-8)Related Product Information
3-AcetylpyridineSupplierMore
  • Company Name:Changzhou DongChen Pharmaceutical Co., Ltd. Gold
  • Tel:13815038136
  • Email:gjf@dcpharmtech.com;gjf@dcpharmtech.com
  • Products Intro:Product Name:3-Acetylpyridine
    CAS:350-03-8
    Purity:99.0%
  •  
  • Company Name:Nanjing Pars Biochem CO.,Ltd Gold
  • Tel:18252001943
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  • Products Intro:Product Name:3-Acetylpyridine
    CAS:350-03-8
    Purity:99% Package:100G/0;1KG/0;10KG/0;100KG/0
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  • Company Name:Shanghai Qiao Chemical Science Co., Ltd Gold
  • Tel:021-58892003-
  • Email:info@qiaochem.com;aaron@qiaochem.com;
  • Products Intro:Product Name:3-Acetylpyridine
    CAS:350-03-8
    Purity:99% Package:as requested
  •  
  • Company Name:Shanghai Taijilin Industrial Co., Ltd. Gold
  • Tel:021-50683728
  • Email:kate@tajilin.com
  • Products Intro:Product Name:3-ACETYL PYRIDINE
    CAS:350-03-8
    Purity:98%HPLC Package:25KG
  •  
  • Company Name:Tianjin Branch Chong pharmaceutical intermediates Co., Ltd. Gold
  • Tel:13207668525 022-60116533
  • Email:saleskc@scipharmacn.com
  • Products Intro:Product Name:3-acetyl pyrdine
    CAS:350-03-8
    Purity:0.99 Package:5KG;25KG
  •