The general procedure for the synthesis of 2-thiazole-methyl-amine from the compound (CAS: 171268-82-9) and water (electrophoretic grade) is as follows:
1. Preparation of GG1 thiazol-2-yl-methylamine azide: triphenylphosphine (2.08 g, 7.9 mmol) was added to a solution of 2-azidomethyl-thiazole (1.11 g, 7.9 mmol) in tetrahydrofuran (THF, 20 mL).
2. Reduction reaction: after 1 h, water (214 μL) and ammonium hydroxide sol (0.5 mL) were added sequentially.
3. Post-treatment: The reaction mixture was stirred overnight and subsequently concentrated under vacuum and purified by fast chromatography (eluent: 5% methanol/dichloromethane) to give the title product 2-thiazolemethanamine as a tan oil (645 mg, 72% yield).
4. The product was characterized by 1H NMR (250 MHz, CDCl3) δ 7.7 (d, 1H, J = 2.0 Hz); 7.25 (d, 1H, J = 2.0 Hz); 4.2 (s, 2H); 1.7 (bs, 2H).
