Basic information Description Reference Safety Related Supplier
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Basic information Description Reference Safety Related Supplier
Rubitecan Basic information
Rubitecan Chemical Properties
  • Melting point:182-186°C
  • alpha D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)
  • Boiling point:816.3±65.0 °C(Predicted)
  • Density 1.63
  • Flash point:106℃
  • storage temp. Room temp
  • pka11.16±0.20(Predicted)
  • Merck 14,8288
  • CAS DataBase Reference91421-42-0(CAS DataBase Reference)
Safety Information
  • Safety Statements 24/25
  • WGK Germany 3
  • RTECS UQ0493300
  • HS Code 29399990
Rubitecan Usage And Synthesis
  • DescriptionRubitecan, marketed by Supergen as Orathecin, is a promising oral treatment for solid melanoma, prostate, breast, ovarian, and other cancers, as well as leukemia. It is a derivative of camptothecin, a topoisomerase inhibitor known from Chinese Traditional Medicine. It selectively targets the critical S-stage of cellular reproduction – particularly in acidic environments, as in many cancer cells – relaxing DNA supercoiling and generating lethal breaks in the DNA. Due to insolubility, its biological delivery mechanism is not yet effective, and it has not been approved for clinical use.
  • Reference
  • Chemical PropertiesYellow Amorphous Powder
  • UsesSemisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic
  • DefinitionChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
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