Description Reference
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Rubitecan

Description Reference
Rubitecan Structure
Rubitecan
  • CAS No.91421-42-0
  • Chemical Name:Rubitecan
  • CBNumber:CB9270138
  • Molecular Formula:C20H15N3O6
  • Formula Weight:393.35
  • MOL File:91421-42-0.mol
Rubitecan Property
  • Melting point: :182-186°C
  • alpha  :D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)
  • Boiling point: :816.3±65.0 °C(Predicted)
  • Density  :1.63
  • Flash point: :106℃
  • storage temp.  :Room temp
  • pka :11.16±0.20(Predicted)
  • Merck  :14,8288
  • CAS DataBase Reference :91421-42-0(CAS DataBase Reference)
  • FDA UNII :H19C446XXB
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • RTECS  :UQ0493300
  • HS Code  :29399990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Rubitecan Price More Price(7)
  • Brand: Sigma-Aldrich
  • Product number: R3655
  • Product name : Rubitecan
  • Purity: 
  • Packaging: 10mg
  • Price: $42.8
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: R3655
  • Product name : Rubitecan
  • Purity: 
  • Packaging: 50mg
  • Price: $169
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: N0822
  • Product name : 9-Nitrocamptothecin
  • Purity: >98.0%(HPLC)
  • Packaging: 100mg
  • Price: $281
  • Updated: 2020/06/24
  • Buy: Buy

Rubitecan Chemical Properties,Usage,Production

  • Description Rubitecan, marketed by Supergen as Orathecin, is a promising oral treatment for solid melanoma, prostate, breast, ovarian, and other cancers, as well as leukemia. It is a derivative of camptothecin, a topoisomerase inhibitor known from Chinese Traditional Medicine. It selectively targets the critical S-stage of cellular reproduction – particularly in acidic environments, as in many cancer cells – relaxing DNA supercoiling and generating lethal breaks in the DNA. Due to insolubility, its biological delivery mechanism is not yet effective, and it has not been approved for clinical use.
  • Reference https://www.sciencedirect.com/topics/medicine-and-dentistry/rubitecan
    https://en.wikipedia.org/wiki/Rubitecan
    https://en.wikipedia.org/wiki/Topoisomerase_inhibitor
    https://en.wikipedia.org/wiki/Camptothecin#cite_note-Y.Pommier_2003-14
    https://www.ncbi.nlm.nih.gov/pubmed/1995300
  • Chemical Properties Yellow Amorphous Powder
  • Uses Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic
  • Definition ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Rubitecan Preparation Products And Raw materials
Raw materials
Preparation Products
Global(150)Suppliers
  • Supplier:
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  • Supplier:
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91421-42-0, RubitecanRelated Search:
  • RFS 2000
  • 9-Nitrocellulose camptothecine
  • 9-NITRO-CPT
  • 9-NITRO-20(S)-CAMPTOTHECIN
  • (4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
  • RUBETICAN
  • RUBITECAN
  • orathecin
  • CAMPTOTHECIN, 9-NITRO-20(S)-
  • Rubitecane
  • (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[346,7]indolizinol[1,2-b]quinoline-3, 14(4H,-12H)-dione
  • 9-NC
  • Oratheci
  • 9-Nitrocamptothecin
  • Rubitecan (RFS 2000)
  • 9-Nitrocamptothecin (Rubitecan)
  • 9-Nitrocamptothecin
  • 9-Nitrocamptothecin&gt
  • 91421-42-0
  • C20H15N3O6
  • Anti-cancer & immunity
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals