7-Ethyl-10-hydroxycamptothecin,98%

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fruit of Camptotheca acuminata.

12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].

[1] Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995;38(3):395-401. DOI:10.1021/jm00003a001