(chlorodifluoroMethyl)triMethylsilane

Product Name(chlorodifluoroMethyl)triMethylsilane
CAS115262-00-5
MFC4H9ClF2Si
MW158.65
EINECS
MOL File115262-00-5.mol

Chemical Properties

Boiling point	90.0±40.0 °C(Predicted)
Density	1.039±0.06 g/cm3(Predicted)
form	liquid
color	colorless

Safety Information

Risk Statements	11
Safety Statements	24/25
TSCA	No
HS Code	29319090

Usage And Synthesis

Uses

(Chlorodifluoromethyl)trimethylsilane, is one of the partially fluorinated compounds, which are often used for diverse applications in materials science, agrochemistry, and the pharmaceutical industry.

Uses

(chlorodifluoroMethyl)triMethylsilane，also known as Hu reagent，it can be used to generate difluorocarbene at higher temperatures catalyzed by chloride ion.

Reactions

(1) Difluoromethylenation of alkenes.
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Refs. 1) Angew. Chem. Int. Ed. 2011, 50, 7153 –7157; 2) Chem. Commun. 2011, 47, 2411–2413.
(2) Difluoromethylenation of alkynes.

Refs. 1) Angew. Chem. Int. Ed. 2011, 50, 7153 –7157; 2) Chem. Commun. 2011, 47, 2411–2413.
(3) Difluoromethylenation of TMSCN.

Ref. J. Org. Chem. 2012, 77, 5850?5855.
(4) Difluoromethylenation of benzyl and alkylzinc halides.

Ref. Org. Lett. 2013, 15, 917 – 919.
(5) Fluorination aminocarbonylation of aldehydes
(chlorodifluoroMethyl)triMethylsilane
Ref. Angew. Chem. Int. Ed. 2022, e202115467