New use of neoaconitrile in the preparation of medicaments for preventing and/or treating myocardial fibrosis and chronic heart failure caused by myocardial fibrosis
Mesaconine is an alkaloidal compound used as a standard reagent for qualitative or quantitative analyses, as well as for experimental biological research.
Mesaconinean, the active ingredient extracted from Aconitum carmichaelii Debx., has cardiovascular effects.
1) Inhibit or reverse myocardial tissue fibrosis; 2) Improve abnormal cardiac remodeling; 3) Improve cardiac dysfunction; 4) Improve the survival rate of mice with chronic heart failure caused by myocardial fibrosis; 5) Fight against myocardial tissue inflammation; 6 ) Inhibition of cardiomyocyte apoptosis; 7) Myocardial enzyme activity in dead mice, and its mechanism of action is related to inhibiting myocardial tissue inflammation and fibrosis caused by adriamycin and resisting cardiomyocyte apoptosis.
