YM155

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2Induces DNA damage.3YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4

YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor.

YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.

ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium.

Survivin

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[1] TAKAHITO NAKAHARA. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.[J]. Cancer research, 2007, 67 17: 8014-8021. DOI:10.1158/0008-5472.can-07-1343
[2] K. OKAMOTO. Overcoming Erlotinib Resistance in EGFR Mutation-Positive Non-Small-Cell Lung Cancer Cells by Targeting Survivin[J]. Annals of Oncology, 2012, 23 1. DOI:10.1016/s0923-7534(20)32199-2
[3] TREVOR G GLAROS. The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage response.[J]. Cancer Chemotherapy and Pharmacology, 2012: 207-212. DOI:10.1007/s00280-012-1868-0
[4] YU-FAN WANG. Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma[J]. Apoptosis, 2013, 19 4: 748-758. DOI:10.1007/s10495-013-0960-1