6-氨基烟酰胺
6-氨基烟酰胺 性质
| 熔点 | 245-248 °C (lit.) |
|---|---|
| 沸点 | 251.97°C (rough estimate) |
| 密度 | 1.2620 (rough estimate) |
| 折射率 | 1.6910 (estimate) |
| 储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | 不溶于水；不溶于乙醇； DMSO 中≥13.7 mg/mL |
| 形态 | 粉末晶体 |
| 酸度系数(pKa) | 15.66±0.50(Predicted) |
| 颜色 | 白色至浅黄色至浅橙色 |
| 水溶解性 | Soluble in Dimethyl sulfoxide (DMSO). Insoluble in water. |
| BRN | 116042 |
| CAS 数据库 | 329-89-5(CAS DataBase Reference) |
| NIST化学物质信息 | Nicotinamide, 6-amino-(329-89-5) |
| EPA化学物质信息 | 6-Aminonicotinamide (329-89-5) |
6-氨基烟酰胺 用途与合成方法
| Target | Value |
|
G6PD
(Cell-free assay) | 0.46 μM(Ki) |
6-Aminonicotinamide (100 nM; 7 days) causes a significant decrease in the human AR+, hormone-sensitive prostate cancer cell lines LNCaP and LAPC4, as well as the CRPC-derivative C4-2 and 22Rv1 cell models. 6-Aminonicotinamide (100 nM ± 10 nM R1881 as indicated for 3 days) increases both basal- and R1881-mediated ROS levels, suggesting 6-Aminonicotinamide is blocking the cells' antioxidant defense. 6-Aminonicotinamide also increases ROS levels in C4-2 cells.
6-Aminonicotinamide (20 mg/kg; i.p.; thress times; days 1, 10 or 11, and 21) alone induces a small but significant tumor growth delay (4.3+/-0.8 days). Treatment with 6-Aminonicotinamide followed by radiation induces a tumor growth delay of 57.0+/-3.8 days in CD8F1 breast tumor model.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 61 |
| 安全说明 | 53-45 |
| 危险品运输编号 | 1655 |
| WGK Germany | 3 |
| RTECS号 | US4550000 |
| Hazard Note | Toxic |
| 危险等级 | 6.1 |
| 包装类别 | II |
| 海关编码 | 29333990 |
6-氨基烟酰胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-W010342 | 6-氨基烟酰胺 | 329-89-5 | 100mg | 500 |
| 2024-01-25 | HY-W010342 | 6-氨基烟酰胺 | 329-89-5 | 10mM * 1mLin DMSO | 550 |
