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Hygromycin B

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Hygromycin B Basic information
Hygromycin B Chemical Properties
  • Melting point:160-180°C
  • alpha D20 +20.2° (c = 1 in water)
  • Boiling point:608.13°C (rough estimate)
  • Density 1.4252 (rough estimate)
  • refractive index 1.6300 (estimate)
  • storage temp. 2-8°C
  • solubility H2O: 50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 30 days.
  • pka7.1, 8.8(at 25℃)
  • form powder
  • color faintly brown to brown
  • PHpH (25g/l, 25℃ ) : 9.5~12.5
  • Water Solubility Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents.
  • Merck 14,4852
  • BRN 6755837
  • EPA Substance Registry SystemHygromycin B (31282-04-9)
Safety Information
MSDS
Hygromycin B Usage And Synthesis
  • Chemical PropertiesWhite to off-white lyophilized powder
  • Usesantibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg
  • UsesHygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome
  • UsesHygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome
  • UsesHygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.
  • General DescriptionAmorphous solid or tan powder.
  • Air & Water ReactionsWater soluble.
  • Reactivity ProfileWeakly basic.
  • Fire HazardFlash point data for Hygromycin B are not available; however Hygromycin B is probably combustible.
  • Safety ProfilePoison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox
Hygromycin B(31282-04-9)Related Product Information
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