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ChemicalBook Product Catalog API Antibiotics Other antibiotic Drugs Hygromycin B

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Hygromycin B NEW

$48.00 200mg

$70.00 500mg

Min. Order
Purity99.9%
Cas No31282-04-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

1YR

United States

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Chemical Properties

Product Name	Hygromycin B
CAS No	31282-04-9
EC-No
Min. Order
Purity	99.9%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Hygromycin B
Description	Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis by interfering with translocation and causing mistranslation of the 70S ribosome. Hygromycin B can be used to screen prokaryotic or eukaryotic cells transfected with hph or hyg resistance genes.
In vitro	METHODS: Mouse PDAC cells 14387T were transfected with lentiCRISPRv2 hygro lentivirus, and after 48 h, the transfected cells were cultured in new medium containing Hygromycin B (500 μg/mL) for two weeks, and the successful transfected cells were screened. RESULTS: Puromycin dihydrochloride screened the lentivirally successfully transfected cells. [1] METHODS: E. coli was cultured in medium containing Hygromycin B (0-8 μg/mL) and cell growth was monitored using a Klett-Summerson colorimeter. RESULTS: Hygromycin B reduced the number of viable cells and increased doubling time in a concentration-dependent manner.Hygromycin B inhibited the number of viable cells by 50% at a concentration of 20 μg/mL, and halved the rate of growth at a concentration of 25 μg/mL. [2]
In vivo	METHODS: To assay antiviral activity in vivo, Hygromycin B (0-5 μmoL/kg) was administered intraperitoneally to MHV-A59-infected BALB/c mice twice daily for three days. RESULTS: Hygromycin B was able to reduce the levels of viral replication and necrotic liver foci in vivo. [3]
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 30 mg/mL (56.87 mM) Saline : 50 mg/mL (94.78 mM)
Keywords	inhibit \| Fungal \| Antibiotic \| Bacterial \| Hygromycin B \| Inhibitor
Related Compound Libraries	Anti-Parasitic Compound Library \| Bioactive Compound Library \| Saccharide and Glycoside Natural Product Library \| Drug Repurposing Compound Library \| Antiparasitic Natural Product Library \| Microbial Natural Product Library \| Natural Product Library for HTS \| Anti-infective Natural Product Library

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Company Profile Introduction

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