Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 (acetate)

Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 is a fluorogenic substrate for β-secretase (BACE).1 Upon cleavage by BACE, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify BACE activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.WARNING This product is not for human or veterinary use.

[1] HYUN-SEOK HONG. FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice.[J]. Journal of Alzheimer’s Disease, 2010, 22 1: 97-105. DOI: 10.3233/jad-2010-100261