Mca-LEVDGW-K(Dnp)-NH2 (trifluoroacetate salt)

Mca-LEVDGW-K(Dnp)-NH2 is a fluorogenic substrate for caspase-4.1 Upon cleavage by caspase-4, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify caspase-4 activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.WARNING This product is not for human or veterinary use.

[1] MIN LU. Activation of multiple caspases and modification of cell surface fas (CD95) in proteasome inhibitor-induced apoptosis of rat natural killer cells[J]. Journal of cellular biochemistry, 2003, 88 3: 482-492. DOI: 10.1002/jcb.10296