Mca-YVADAP-K(Dnp)-OH (trifluoroacetate salt)

Mca-YVADAP-K(Dnp)-OH is a substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2).1,2 Upon cleavage by caspase-1 or ACE2, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify enzyme activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.WARNING This product is not for human or veterinary use.

[1] CHAD VICKERS. Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase*[J]. The Journal of Biological Chemistry, 2002, 8 1: 14838-14843. DOI: 10.1074/jbc.m200581200
[2] MASATO ENARI. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis[J]. Nature, 1996, 380 6576: 723-726. DOI: 10.1038/380723a0