Mca-HQKLVFFA-K(Dnp)-NH2 (trifluoroacetate salt)

Mca-HQKLVFFA-K(Dnp)-NH2 is a fluorogenic substrate for α-secretase.1 Upon cleavage by α-secretase, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify α-secretase activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.WARNING This product is not for human or veterinary use.

[1] HIROAKI FUKUMOTO. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer’s disease.[J]. Journal of Neuroscience, 2010, 30 33: 11157-11166. DOI: 10.1523/jneurosci.2884-10.2010