三七素
三七素 性质
| 密度 | 1.596±0.06 g/cm3 (20 ºC 760 Torr) |
|---|---|
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 0.1MHCl：可溶性2mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 1.99±0.10(Predicted) |
| 颜色 | 白色至米色 |
| 旋光度 (Optical Rotation) | [α]/D -17 to -23°, c = 0.5 (Solvent: 4N HCl) |
| InChI | InChI=1S/C5H8N2O5/c6-2(4(9)10)1-7-3(8)5(11)12/h2H,1,6H2,(H,7,8)(H,9,10)(H,11,12)/t2-/m0/s1 |
| InChIKey | NEEQFPMRODQIKX-REOHCLBHSA-N |
| SMILES | C(O)(=O)[C@H](CNC(C(O)=O)=O)N |
三七素 用途与合成方法
PHD-2
Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2. Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN).
Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models.
三七素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-N1477 | 三七素 | 5302-45-4 | 5 mg | 1650 |
| 2026-06-05 | HY-N1477 | 三七素 | 5302-45-4 | 10 mM * 1 mL in DMSO | 1815 |
