Spathulenol is a tricyclic sesquiterpene alcohol which has a basic skeleton similar to the azulenes,it occurs in oregano among other plants.
Spathulenol is a colorless to pale yellow clear liquid.
Spathulenol is isolated from psidium guineense Sw, has antioxidant, anti-inflammatory, anti-proliferative and anti-mycobacterial activities. It shows high antioxidant activity in DPPH system with IC50 of 85.60 μg/mL.
Eucalyptol is an organic alcohol compound, mainly used for content determination and experimental research, not for other purposes.
Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].
ChEBI: Spathulenol is a tricyclic sesquiterpenoid that is 4-methylidenedecahydro-1H-cyclopropa[e]azulene carrying three methyl substituents at positions 1, 1 and 7 as well as a hydroxy substituent at position 7. It has a role as a volatile oil component, a plant metabolite, an anaesthetic and a vasodilator agent. It is a sesquiterpenoid, a carbotricyclic compound, a tertiary alcohol and an olefinic compound.
Spathulenol (oral administration; 300 mg/kg) shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model[1].
In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature and
oxygenation conditions, PG-1 exhibits a high activity with an IC50 value of 26.13 μg/mL, respectively, which is
comparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA,
which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations[1].
[1] Nascimento KF, et al. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol.J Ethnopharmacol. 2018 Jan 10;210:351-358. DOI:
10.1016/j.jep.2017.08.030
