Remivox,Janssen,W. Germany,1980
Cardiac depressant (anti-arrhythmic).
ChEBI: Lorcainide is a member of acetamides.
To a stirred suspension of 5 parts of N-(4-chlorophenyl)-N-(4-piperidinyl) benzeneacetamide, 5 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of butanol is added dropwise 4 parts of 2-bromopropane at room temperature. After the addition is complete, the whole is stirred and refluxed for 20 hours. Then the second portion of 4 parts of 2-bromopropane
is added and stirring and refluxing is continued for another 19 hours. The
reaction mixture is cooled, filtered and the filtrate is evaporated. From the oily
free base, the hydrochloride salt is prepared in the conventional manner in
1,1'-oxybisethane and 2-propanone. The precipitated solid salt is filtered off
and crystallized from a mixture of 2-propanone and 2-propanol, yielding 2
parts of N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]
benzeneacetamide hydrochloride; melting point 263°C.
Side effects include
insomnia and gastrointestinal disturbances.
