PEPTIDE YY, PORCINE

Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system[1][2][3].

NPY Y₂ receptor

[1] Lundberg JM, et al. Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc Natl Acad Sci U S A. 1982 Jul;79(14):4471-5. DOI:10.1073/pnas.79.14.4471
[2] Ding WG, et al. Neuropeptide Y and peptide YY immunoreactivities in the pancreas of various vertebrates. Peptides. 1997;18(10):1523-9. DOI:10.1016/s0196-9781(97)00237-4
[3] Olsen J, et al. Metabolism of peptide YY 3-36 in G?ttingen mini-pig and rhesus monkey. Peptides. 2016 Apr;78:59-67. DOI:10.1016/j.peptides.2016.01.010