[Appearance] White crystalline powder with bitter taste [Solubility] Almost insoluble in water, slightly soluble in 95% ethanol, soluble in ether, soluble in chloroform [Melting point] 134-137℃ [Clarity and color of solution] 5ml1% 1N NaOH solution should be clarified and colorless [Acidity] 6.0-6.8 [Relevant impurities] Phenobarbital ≤0.8% [Diphenyl derivatives] ≤0.4% (TLC) Chloride] ≤0.005% [Sulfate] ≤0.025% [Sulfate ash] ≤0.1% [Heavy metal] ≤0.001% [Content] ≥99.0%
is used in preparation method and composition for treating epilepsy including administering a Cholecystokinin-2 receptor antagonist and combination with antiepileptic agents.
Moderately toxic by ingestion.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits toxicfumes of NOx.
Phenobarbital was synthesized using silver salt of phenobarbital and benzoyl chloride in catalyst-free reaction with about 20% yield. Benzoylphenobarbital was synthesized from phenobarbital and benzoyl chloride using 4 dimethylaminopyridine (abbreviated as DM AP) as a catalyst and triethylamine as an acid-fixing agent in 64% yield, w (benzoylphenobarbital) = 99%.
