ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Benzimidazo[2,1-a]benz[d,e]isoquinolion-7-one

Benzimidazo[2,1-a]benz[d,e]isoquinolion-7-one

Product NameBenzimidazo[2,1-a]benz[d,e]isoquinolion-7-one
CAS23749-58-8
MFC18H10N2O
MW270.28
EINECS245-865-7
MOL File23749-58-8.mol

Chemical Properties

Melting point	189 °C
Boiling point	613.6±38.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
pka	2.05±0.20(Predicted)
form	powder
color	Bright yellow
InChI	InChI=1S/C18H10N2O/c21-18-13-8-4-6-11-5-3-7-12(16(11)13)17-19-14-9-1-2-10-15(14)20(17)18/h1-10H
InChIKey	NZBSAAMEZYOGBA-UHFFFAOYSA-N
SMILES	C12=NC3=CC=CC=C3N1C(=O)C1=CC=CC3=CC=CC2=C13

Safety Information

HS Code

2933998090

Usage And Synthesis

Uses

AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].

Application

BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE is a derivative of benzimidazo[2,1-a]benz[d,e]isoquinolion-7-one fluorophore, which is known to enter the cells and localize into the acidic organelles^[2].

Properties and Applications

TEST ITEMS	SPECIFICATION
APPEARANCE	YELLOW POWDER
SHADE	GREENISH
HEAT RESISTANCE	260 °C min
LIGHT FASTNESS	5-6
ACID RESISTANCE	5
ALKALI RESISTANCE	5
WATER RESISTANCE	5
DENSITY	1.20 g/cm ³
RESIDUE ON 80 MESH	5.0% max
WATER SOLUBLE	1.0% max
VOLATITE 105 °C	1.0% max
TINTING STRENGTH	100-105 %
WEIGHT METAL TOTAL	50ppm max

References

[1] Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042. DOI:10.1021/acsptsci.2c00253
[2] Faggi, E., Luis, S. V., & Alfonso, I. (2019). Sensing, Transport and Other Potential Biomedical Applications of Pseudopeptides. Current Medicinal Chemistry, 26 21<, 4065–4097. https://doi.org/10.2174/0929867325666180301091040

Benzimidazo[2,1-a]benz[d,e]isoquinolion-7-one Supplier

Benzimidazo[2,1-a]benz[d,e]isoquinolion-7-one manufacturers

Related Product Information

Send Inquriy