Uses
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].
Application
BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE is a derivative of benzimidazo[2,1-a]benz[d,e]isoquinolion-7-one fluorophore, which is known to enter the cells and localize into the acidic organelles
[2].
Properties and Applications
|
TEST ITEMS
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SPECIFICATION
|
|
APPEARANCE
|
YELLOW POWDER
|
|
SHADE
|
GREENISH
|
|
HEAT RESISTANCE
|
260 °C min
|
|
LIGHT FASTNESS
|
5-6
|
|
ACID RESISTANCE
|
5
|
|
ALKALI RESISTANCE
|
5
|
|
WATER RESISTANCE
|
5
|
|
DENSITY
|
1.20 g/cm
3
|
|
RESIDUE ON 80 MESH
|
5.0% max
|
|
WATER SOLUBLE
|
1.0% max
|
|
VOLATITE 105 °C
|
1.0% max
|
|
TINTING STRENGTH
|
100-105 %
|
|
WEIGHT METAL TOTAL
|
50ppm max
|
References
[1] Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042. DOI:
10.1021/acsptsci.2c00253[2] Faggi, E., Luis, S. V., & Alfonso, I. (2019). Sensing, Transport and Other Potential Biomedical Applications of Pseudopeptides. Current Medicinal Chemistry, 26 21<, 4065–4097.
https://doi.org/10.2174/0929867325666180301091040
![BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE Structure](https://www.chemicalbook.com/CAS/GIF/23749-58-8.gif)
